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As for the features of the relationship between AAS use and somatoform and/or eating disorders, Pope and Katz [54] showed that 18.2% of 88 male weightlifters who abused AASs reported a history of muscle dysmorphia, compared to none of the 68 male weightlifters who did not use AASs (controls). Blouin and Goldfield [105] examined the relationship between body image disturbances, eating attitudes, and AAS use in 43 male bodybuilders vs. 48 runners and 48 martial artists of the same sex, all recruited from fitness centers. Bodybuilders showed significantly greater body dissatisfaction, with a high tendency to bulk and thinness, and increased inclinations towards bulimia than the other two groups. Additionally, they reported higher perfectionism and ineffectiveness, as well as lower self-esteem. They also consumed more AASs and had freer attitudes towards AAS use. The main reason for taking AASs, according to AAS users, was physical improvement: AAS users reported a stronger drive to put on muscle mass in the form of bulk, more maturity fears, and greater tendencies towards bulimia than AAS nonusers. Thus, male bodybuilders seem to be at risk for body image disturbances and the associated psychopathological characteristics that have been commonly observed in patients with eating disorders. These psycho-pathological characteristics also appear to predict AAS use in this group of men.
The risks and benefits of different screening tests vary. See Table 1 for characteristics of recommended screening strategies, which may include combinations of screening tests. Because of limited available evidence,9,10 the USPSTF recommendation does not include serum tests, urine tests, or capsule endoscopy for colorectal cancer screening. Recommended stool-based and direct visualization screening tests are described below.
Two prospective cohort studies (n=436,927) in US-based populations reported on colorectal cancer outcomes after colonoscopy screening.9,10 One study among health professionals found that after 22 years of follow-up, colorectal mortality was lower in persons who reported receiving at least 1 colonoscopy (adjusted hazard ratio, 0.32 [95% CI, 0.24-0.45]),39 although findings were no longer significant after 5 years for adults with a first-degree relative with colorectal cancer. This study included persons younger than 50 years, although results for this age group were not reported separately. Another cohort study among Medicare beneficiaries reported that the risk of colorectal cancer was significantly lower in adults aged 70 to 74 years (but not aged 75 to 79 years) 8 years after receiving a screening colonoscopy (standardized risk, 0.42% [95% CI, 0.24%-0.63%]).40 One large, prospective cohort study (n=5,417,699) from Taiwan reported on colorectal cancer mortality after introduction of a nationwide screening program with FIT in adults aged 50 to 69 years.41 After 1 to 3 rounds of biennial FIT screening, lower colorectal cancer mortality was found at 6 years of follow-up (adjusted relative risk, 0.90 [95% CI, 0.84-0.95]).
Harms from CT colonography are uncommon (19 studies; n=90,133), and the reported radiation dose for CT colonography ranges from 0.8 to 5.3 mSv (compared with an average annual background radiation dose of 3.0 mSv per person in the US).9,10 Accurate estimates of rates of serious harms from colonoscopy following abnormal CT colonography results are not available. Extracolonic findings on CT colonography are common. Based on 27 studies that included 48,235 participants, 1.3% to 11.4% of examinations identified extracolonic findings that required workup.9,10 Three percent or less of individuals with extracolonic findings required definitive medical or surgical treatment for an incidental finding. A few studies suggest that extracolonic findings may be more common in older age groups. Long-term clinical follow-up of extracolonic findings was reported in few studies, making it difficult to know whether it repres
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