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Miniaturized Analytical Devices.epub
Miniaturized Analytical Devices.epub >>>>> https://urluss.com/2tlG7E
Miniaturized Analytical Devices.epub
Citation: Loreck K, Mitrenga S, Meemken D, Heinze R, Reissig A, Mueller E, et al. (2019) Development of a miniaturized protein microarray as a new serological IgG screening test for zoonotic agents and production diseases in pigs. PLoS ONE 14(5): e0217290.
Developments in bioanalytical methods have obviously been a key driver in making microsampling a practical alternative in both preclinical and clinical work. Matching the bioanalytical method with the microsample is key to success. Bioanalysis must be able to deliver reliable data from small amounts of analyte in complex matrices such as blood or saliva. With its nanoliter-scale flow-through technology, Gyrolab system is an immunoassay platform that has proved its value in several studies based on microsampling.
In this work we study the limits of miniaturization of a 90-degree hybrid coupler working in the L, C and S bands, with respect to a number of performance parameters aimed at its application for balanced detection. We investigate the main effects responsible for the degradation of the performance of the devices during miniaturization, and establish the minimal dimension that such devices can have without significant degradation for photonic applications such as balanced detection. The miniaturized device in InP generic technology has a footprint of only 2200μm2, more than 5 times smaller than the conventional device used as reference. The scaling approach is based on the use of the number of propagating modes which are sustained in both the miniaturized MMI and port waveguides as scaling parameters. This approach allows us to generalize the miniaturization problem from a specific platform and offers a methodology which is flexible and transferable to multiple platforms. We tested the scaling methodology based on the number of modes in other platforms commonly used in integrated photonics, such as Si/SiO2 (SOI), TriPleX or polymer platforms, obtaining comparable results and proving the universality of our approach, finally we performed a fabrication tolerance analysis of the miniaturized devices.
N2 - In this work we study the limits of miniaturization of a 90-degree hybrid coupler working in the L, C and S bands, with respect to a number of performance parameters aimed at its application for balanced detection. We investigate the main effects responsible for the degradation of the performance of the devices during miniaturization, and establish the minimal dimension that such devices can have without significant degradation for photonic applications such as balanced detection. The miniaturized device in InP generic technology has a footprint of only 2200μm2, more than 5 times smaller than the conventional device used as reference. The scaling approach is based on the use of the number of propagating modes which are sustained in both the miniaturized MMI and port waveguides as scaling parameters. This approach allows us to generalize the miniaturization problem from a specific platform and offers a methodology which is flexible and transferable to multiple platforms. We tested the scaling methodology based on the number of modes in other platforms commonly used in integrated photonics, such as Si/SiO2 (SOI), TriPleX or polymer platforms, obtaining comparable results and proving the universality of our approach, finally we performed a fabrication tolerance analysis of the miniaturized devices.
AB - In this work we study the limits of miniaturization of a 90-degree hybrid coupler working in the L, C and S bands, with respect to a number of performance parameters aimed at its application for balanced detection. We investigate the main effects responsible for the degradation of the performance of the devices during miniaturization, and establish the minimal dimension that such devices can have without significant degradation for photonic applications such as balanced detection. The miniaturized device in InP generic tech